4 experimental and clinical applications of tissue engineering in omfs
Báo cáo y học: "Quantitative ultrasound can assess the regeneration process of tissue-engineered cartilage using a complex between adherent bone marrow cells and a three-dimensional scaffold" docx
... cartilage-like tissue made by tissue engineering in the treatment of cartilage defects of the knee J Bone Joint Surgr 2002, 84:571-578 Shieh SJ, Terada S, Vacanti JP: Tissue engineering auricular ... concepts in tissue engineering J Biomed Mater Res 1998, 43:422-427 Isogai N, Landis W, Kim TH, Gerstenfeld LC, Upton J, Vacanti JP: Formation of phalanges and small joints by tissue- engineering J ... determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid Arch Biochem Biophys 1961, 93:440-447 Chen G, Sato T, Ushida T, Ochiai N, Tateishi T: Tissue...
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Báo cáo y học: "The Influence of Hyperbaric Oxygen Treatment on the Healing of Experimental Defects Filled with Different Bone Graft Substitutes"
... These interesting and previously unreported findings suggest the necessity of multidisciplinary study designs which take into account different characteristics of the tissues involved in host tissue ... fractures (29) and also the torsional strength of distracted rabbit tibiae(30)Nilsson et al (31) compared the influences of heparin, dextrane and HBOT in preventing soft and hard tissue damages in experimentally ... the inconsistency of animal models and HBOT procedures, our findings showed a similar pattern in the healing of control defects in rats given HBOT In light microscopy, we observed an increase in...
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Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc
... MAP kinase signaling pathway TAM67 retains the DNA binding and leucine-zipper region of c-Jun, but it lacks the transactivation domain of c-Jun (amino acids 1–122) It thus blocks the binding of ... event in determining the susceptibility to apoptosis through maintaining the integrity of the mitochondria and inhibiting activation of the caspase cascade [37] High expression levels of antiapoptotic ... AP1 DNA binding activity increased within h following EGF treatment and peaked at h following the treatment (Fig 5A) We also examined the effect of PD98059 on this binding activity and, as expected,...
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Investigation of au and in as solvents for the growth of silicon nanowires on si(1 1 1)
... explain differences in droplet formation between indium and gold, we will consider in the following the effects of different diffusion coefficients of gold and indium on silicon, the solubility of ... nanowires after flooding the chamber with diluted silane and explained the absence of nanowires by considering the surface tension of indium and the low solubility of silicon in indium Iacopi et ... behavior of gold and indium on Si(1 1) has been described and analyzed An explanation based on differences of solubilities of surface atoms in gold and indium and on the different surface energies of...
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báo cáo hóa học:" SPECT/CT-plethysmography – non-invasive quantitation of bone and soft tissue blood flow" ppt
... cylinder is composed of soft tissue (mainly muscles and skin) and "hard" tissue (bone and bone marrow) The soft tissue volume (VS) and blood pool (RS) are calculated as follows: VS = VL-VB and ... in minute http://www.josr-online.com/content/3/1/36 RS – scintigraphic reading within the soft tissue compartment RL – scintigraphic reading within the entire limb compartment During the infinitesimal ... and blood pool activity of the bone (including bone marrow) and soft tissue were determined using segmentation based on thresholds within a virtual cylinder consistent of 3–4 slices (slice thickness...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx
... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; ... fresh tumor tissues were minced in DMEM containing 10% FBS supplemented with 100 U/mL penicillin and 100 μg/mL streptomycin The cell suspension containing small tissue pieces was plated in a 10 cm-culture ... may induce the tyrosine phosphorylation of FAK in cells within GCTs Correlation between the clinical stage and pY-Flt-1 and pY-FAK expression in GCTs To determine the biological significance of...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx
... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; ... fresh tumor tissues were minced in DMEM containing 10% FBS supplemented with 100 U/mL penicillin and 100 μg/mL streptomycin The cell suspension containing small tissue pieces was plated in a 10 cm-culture ... may induce the tyrosine phosphorylation of FAK in cells within GCTs Correlation between the clinical stage and pY-Flt-1 and pY-FAK expression in GCTs To determine the biological significance of...
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Báo cáo y học: "Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget''''s disease of bone in an Italian family" pps
... gene mutations and clinical manifestations of PDB [7] or the role of genetic testing in asymptomatic carriers within affected families The findings described in this paper are of interest with ... M404V is able to cause the loss of monoubiquitin binding and impair in vitro Lys48-linked polyubiquitin binding, although these effects were reported only when the binding experiments were performed ... design and coordination, acquisition of data, analysis and interpretation of data, and was fully involved in drafting the manuscript and revising it critically for important intellectual content...
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Báo cáo y học: " Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis" ppt
... for hyperplasia of the synovial lining layer, 1.9, 1.1 and 0.3 points for activation of the sublining stroma, and 2.1, 0.8 and 0.1 points for inflammatory infiltration in RA, OA and ND, respectively ... understand precisely the network of morphogen action and regulation in the joint, because injection of BMP-2 induced osteophyte formation in a murine model [9] Thus, the interaction of BMPs and inhibitors ... release of inflammatory cytokines and destructive proteases [2] Increases in knowledge about inflammatory cytokines and cytokine networks in chronic joint diseases has promoted the development of...
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Báo cáo y học: "Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation" pps
... IFN, interferon; IL, interleukin; TNF, tumour necrosis factor uate distinct immune responses in an autocrine fashion [37,38,40], but the manner in which they are likely to interact in specific tissues ... of increased generation of active glucocorticoids in affected tissues Future studies of 11β-HSD1 in vivo will help to clarify its importance for the resolution, persistence and treatment of inflammation ... Ross E, Bofill M, Martin S, Salmon M, Buckley CD: Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns...
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Báo cáo y học: "Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts" potx
... Discussion As an increasing amount of literature is demonstrating the involvement of bone tissue in the initiation/progression of OA, a better understanding of this tissue is clearly of utmost importance ... H, Onishi Y, Inukai K, Anai M, Fukushima Y, et al.: 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain J Biol Chem ... phosphorylation of a number of intracellular proteins, such as IRS-1, Shc and Gab1 This gives rise to the activation of Ras and PI3K, thus resulting in the activation of MAPK and PKB [40] In our diseased...
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Báo cáo y học: " A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab" docx
... observed in clinical nonresponders to infliximab is in accordance with the findings of a recent study [8] that demonstrated protective effects on joint destruction in the absence of clinical response ... markers of bone turnover and clinical parameters or bone mineral density values On looking for correlation between bone markers and clinical parameters in the whole population (control and infliximab ... were included in several analysis of covariance models for bone mineral density (BMD) variations (final values minus initial values) to analyze the effect of cofactors (continuous variables and...
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Báo cáo y học: "Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling" pot
... breakdown of the cartilage and joint space narrowing, there is thickening and sclerosis of subchondral bone, development of cysts and bony overgrowth at the margins of the joint Despite an increase in ... levels of bone remodelling seen in OA bone and perhaps a net gain of under-mineralized bone rather than the net loss of bone volume seen in OP Interestingly, and in contrast to the large number of ... swap strategy This involved swapping of Cy3 and Cy5 labelling of the samples in each pair for each group of paired samples to balance for potential dye incorporation and signal intensity bias It...
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báo cáo khoa học: " Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring Insulin-Like Growth Factor-1 in a Preclinical Model of Human Breast Cancer" doc
... Davidson B: Diagnostic and prognostic role of the insulin growth factor pathway members insulin-like growth factor-II and insulin-like growth factor binding protein-3 in serous effusions Hum ... Plasma insulin-like growth factor-I and serum IGF-binding protein can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in African-American ... 0.15’’cells containing independent CNT circuits (upper and lower) An enlarged view of a cell indicating the contact surfaces of the source and the drain is shown to the right of the wafer Gate...
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Báo cáo y học: " Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells" potx
... βcasein) (D and E) Involvement of Stat3 and Stat5 in the formation of SIE- (D) and β-casein- (E) binding complexes in HTLV-1-infected T-cell lines EMSA was performed with nuclear extracts of the indicated ... blocks the phosphorylation of Stat5 and Jak3, and DNA-binding activity of Stat5 of Constitutive activation of Stat3- and Stat5-DNA binding activity in HTLV-1-infected T-cell lines Electrophoretic mobility ... activation of Stat3 and Stat5 through inhibition of Jak kinases in HTLV-1-infected T-cell lines The regulation of phosphorylation of Stat3 and Stat5 by Jak kinases was investigated with Jak selective inhibitor,...
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Báo cáo y học: "Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis." pptx
... COPD, site of infection, and leukocytes; the nonsurviving sepsis patients showed a higher incidence of diabetes mellitus, higher levels of lactic acid and creatinine, prolonged aPTT, and reduced ... surviving and nonsurviving patients, respectively; and in the study by Hoffmann et al [11], the mean APACHE-II scores were 14 and 23 in surviving and nonsurviving patients, respectively The role of ... in sepsis remains unclear; but the results of some studies indicate that MMPs play a certain role in the recruitment of leukocytes from the bloodstream to the site of infection [26-28], and in...
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Suitability of insulin like growth factor 1 (IGF1) as a measure of relative growth rates in lingcod
... number of individuals in the analysis differed from the number stocked at the beginning of the experiment owing to mortality Variation in IGF1 in Wild Lingcod We collected 146 lingcod (97 males and ... found in other species to suggest that IGF1 may be useful as a relative index of growth in lingcod and that further work in the laboratory and in the field is warranted The in situ measurements of ... W Dickhoff 1998 Insulin-like growth factor-I and environmental modulation of growth during smoltification of spring Chinook salmon Oncorhynchus tshawytscha General and Comparative Endocrinology...
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Differentiation of bone marrow derived mesenchymal stem cells (BM MSCs) using engineered nanofiber substrates
... explosion in tissue engineering research has revolutionized our understanding in modulating stem cell fate and behavior, translating into potential clinical applications for regenerative medicine Such ... Alizarin red staining of various substrates after 14 days of culture in normal and osteogenic media Scalebar: 100 µm Fig 4.16: Alizarin red staining of various substrates after 28 days of culture in ... Nanofibres for Bone Tissue Engineering Scaffolds Bioceramics 19, 19th International Symposium on Ceramics in Medicine, The Annual Meeting of the International Society for Ceramics in Medicine,10-13...
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Tissue engineering approaches to tendon repair studies on the use of bone marrow stromal cells and knitted poly (d, l lactide co glycolide scaffold
... 2.4 Tissue Engineering Approaches To Improve Tendon Healing 2.3.1 Tissue Engineering Principles The term tissue engineering was initially defined in 1988 as “application of the principles and ... principles of tissue engineering and current tissue engineering studies in developing grafts to facilitate tendon regeneration can serve as the foundation for this tendon tissue engineering work ... tissue engineering as “an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain or improve tissue...
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